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2381089-83-2 Retatrutide CAS NO.2381089-83-2
- FOB Price: USD: 6.00-65.00 /Gram Get Latest Price
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T,Other
- Available Specifications:
A(10-100)GramA(1-10)KilogramB(10-100)Gram
- Product Details
Keywords
- Retatrutide
- cas
- 2381089-83-2
Quick Details
- ProName: 2381089-83-2 Retatrutide
- CasNo: 2381089-83-2
- Molecular Formula: 200-001-8
- Appearance: White powder
- Application: healing drugs
- DeliveryTime: Stock
- PackAge: 200/Kilograms
- Port: Shanghai/tianjin
- ProductionCapacity: 1000 Metric Ton/Day
- Purity: 99%
- Storage: Sealed and preserved
- Transportation: By sea By air
- LimitNum: 10 Gram
- Moisture Content: DMSO: >20mg/mL
- Impurity: 11
- 11: 3.488g/L(temperature not stated)
Superiority
Product Description
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High quality and competitive price.
1. We can provide samples for testing.
2. All purity >99%.
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Details
Biological Activity
Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).
Retatrutide acetate inhibits for human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate has efficacy for mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively.
Retatrutide (LY3437943) acetate engages GCGR in vivo and can improve glucose tolerance in an ipGTT through either the GIP or GLP-1 receptors. Retatrutide acetate causes great body weight loss and increases energy expenditure through glucagon receptor activatio. Retatrutide acetate can be used for the research of obesity.
Chemical Information
| Molecular Weight | 4791.38 |
| Formula | C221H342N46O68.C2H4O2 |
| CAS Number | 2381089-83-2 (free base) |
| Form | Solid |
| Solubility (25°C) | Water 10 mg/mL |
| Storage | Store at ≤ -20°C, protect from light, dry, sealed |
Conversion of different model animals based on BSA (PMID: 27057123)
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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